IMAGEMEND is a study with focus
on development of effective imaging
tools for diagnosis, monitoring
and management of mental disorders.

Project leader

Prof. Andrew McIntosh Phone: +44 131 537 6274 Fax: +44 131 537 6508 E-mail

Project co-leader

Prof. Jeremy Hall Phone: +44 2920 879043 Fax: +44 131 537 6508 E-mail

Project staff

Dr. Heather Whalley Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Dr. Jessika Sussmann Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Dr. Liana Romaniuk Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Ms. Alix Macdonald Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Institute presentation

The Division of Psychiatry in Edinburgh is internationally renowned for prospective imaging studies of people at high genetic risk of schizophrenia and bipolar disorder, and for its work in the field of psychiatric genetics and genetic imaging.

We have led 3 recent cohort studies of people at high risk of psychosis (2 in schizophrenia and 1 in bipolar disorder), a study of individuals with affective psychosis and a number of investigations which define the risk state by the presence of one or many common genetic variants (e.g. DISC1, NRG1, DGKH, CACNA1C, polygenic risk factors). We have also discovered a number of clinical, cognitive and imaging predictors of illness in these cohorts (e.g. McIntosh et al, Biol Psychiatry 2011; Whalley et al, Biol Psychiatry 2011; Hall et al Nat Neurosci 2006). Profs Jeremy Hall and Andrew McIntosh have also conducted (e.g. Selvaraj Bip Dis 2010;) and participated successfully in a number of international collaborative studies, resulting in internationally leading research, high impact publications (e.g. Stein et al 2012 Nat Gen; Ripke Nat Gen 2011) providing a pathway for future target identification and drug development.

Project leader

Prof. Andreas Papassotiropoulos, MD Phone: +41612670599 Fax: +4612670587 E-mail

Prof. Dominique de Quervain, MD Phone: +41612670237 Fax: +4612670241 E-mail

Project staff

Klara Spalek, MSc Phone: +41612670226 Fax: +4612670241 E-mail

Institute presentation

The Transfaculty Research Platform Molecular and Cognitive Neuroscience (MCN) has the distinction of being the first transfaculty endeavour of the University of Basel and has developed into a thriving hub for psychological and psychiatric research. MCN’s research programmes focus on such neuroscience-related aspects as the molecular and genetic mechanisms of human cognition, the mechanisms promoting mental health or leading to mental disease, the neural mechanisms leading to decision-making, dementia, and cognitive neuroscience. Research methods include cutting-edge genomics, transcriptomics, and methylomics, state-of-the-art brain imaging, electrophysiology and virtual reality laboratories, as well as modern facilities for behavioral observation and cognitive testing. This research plan has been already extremely fruitful and has put Basel’s psychology and psychiatry research already at a top level of international competition and visibility, as shown by its publications in Science, Nature Neuroscience and PNAS, among others. For example, we were the first group to identify memory-related genes in human by using high-throughput genotyping methods and implementing comprehensive multi-locus statistical methods as well as functional brain imaging (Science 2006). Our work has been commented in detail by editors of high-ranked journals (e.g. Lancet Neurology), and was declared by the editors of Science as a “Breakthrough of the Year”.

Key publications

• de Quervain, D.J., Roozendaal, B. & McGaugh, J.L. (1998). Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature 394, 787-90.
• Papassotiropoulos, A., Stephan. D.A., Huentelman, M.J., Hoerndli, F.J., Craig, D.W., Pearson, J.V., Huynh, K.D., Brunner, F., Corneveaux, J., Osborne, D., Wollmer, M.A., Aerni, A., Coluccia, D., Hänggi, J., Mondadori, C.A., Buchmann, A., Reiman, E.M., Caselli, R.J., Henke, K. & de Quervain, D.J.F. (2006). Common KIBRA alleles are associated with human memory performance. Science 314(5798), 475-478.
• de Quervain, D.J.F., Henke, K., Aerni, A., Coluccia, D., Wollmer, M.A., Hock, C., Nitsch, R.M. & Papassotiropoulos, A. (2003). A functional genetic variation of the 5-HT2a receptor affects human memory. Nature Neuroscience 6, 1141-1142.
• de Quervain, D.J.F., Kolassa, I.T., Ertl, V., Onyut, P.L., Neuner, F., Elbert, T. & Papassotiropoulos, A. (2007). A deletion variant of the alpha2b-adrenoceptor is related to emotional memory in Europeans and Africans. Nature Neuroscience 10(9), 1137-1139.
• Papassotiropoulos, A., Gerhards, C., Heck, A., Ackermann, S., Aerni, A., Schicktanz, N., Auschra, B., Demougin, P., Elbert, T., Ertl, V., Gschwind, L., Hanser, E., Huynh, K.D., Jessen, F., Kolassa, I.T., Milnik, A., Paganetti, P., Spalek, S., Vogler, C., Muhs, A., Pfeifer, A. & de Quervain, D.J.F. (2013). Human genome-guided identification of memory-modulating drugs. Proc Natl Acad Sci U S A 110(46):E4369-74.
• de Quervain, D.J.F., Kolassa, I.T., Ackermann, S., Aerni, A., Boesiger, P., Demougin, P., Elbert, T., Ertl, V., Gschwind, L., Hadziselimovic, N., Hanser, E., Heck, A., Hieber, P., Huynh, K.-D., Klarhöfer, M., Luechinger, R., Rasch, B., Scheffler, K., Spalek, K., Stippich, C., Vogler, C., Vukojevic, V., Stetak, A. & Papassotiropoulos, A. (2012). PKCa is genetically linked to memory capacity in non-traumatized individuals and to traumatic memory and PTSD in genocide survivors. Proc Natl Acad Sci U S A 109(22), 8746-51.
• Rasch, B., Spalek, K., Buholzer, S., Lüchinger, R., Bösiger, P., Papassotiropoulos, A. & de Quervain, D.J.F. (2009). A functional genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. Proc Natl Acad Sci U S A 106(45), 19191–19196.
• de Quervain, D.J.F. & Papassotiropoulos, A. (2006). Identification of a genetic cluster influencing memory performance and hippocampal activity in humans. Proc Natl Acad Sci U S A 103(11), 4270-4274.
• Papassotiropoulos, A. & de Quervain, D.J.F. (2011). Genetics of human episodic memory: Dealing with complexity. Trends in Cognitive Sciences 15(9), 381-387.

The Scientific and Ethical Advisory Board (SEAB) is a consultative body which is formed to ensure and improve the scientific performance and the quality of results of IMAGEMEND. Three renowned experts from the relevant scientific fields of IMAGEMEND have agreed to be part of the IMAGEMEND Scientific and Ethical Advisory Board.

Dr. Ilina Singh Reader in Bioethics & Society in Social Science, Health & Medicine and cross-appointed to the Institute of Psychiatry, Kings College London CV

Prof. Dr. med. Peter Propping Institute of Human Genetics, Biomedical Center, University of Bonn CV

Prof. Steven Potkin Director Brain Imaging Center at UC Irvine