Project leader

Prof. Andrew McIntosh Phone: +44 131 537 6274 Fax: +44 131 537 6508 E-mail

Project co-leader

Prof. Jeremy Hall Phone: +44 2920 879043 Fax: +44 131 537 6508 E-mail

Project staff

Dr. Heather Whalley Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Dr. Jessika Sussmann Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Dr. Liana Romaniuk Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Ms. Alix Macdonald Phone: +44 131 537 6000 Fax: +44 131 537 6508 E-mail

Institute presentation

The Division of Psychiatry in Edinburgh is internationally renowned for prospective imaging studies of people at high genetic risk of schizophrenia and bipolar disorder, and for its work in the field of psychiatric genetics and genetic imaging.

We have led 3 recent cohort studies of people at high risk of psychosis (2 in schizophrenia and 1 in bipolar disorder), a study of individuals with affective psychosis and a number of investigations which define the risk state by the presence of one or many common genetic variants (e.g. DISC1, NRG1, DGKH, CACNA1C, polygenic risk factors). We have also discovered a number of clinical, cognitive and imaging predictors of illness in these cohorts (e.g. McIntosh et al, Biol Psychiatry 2011; Whalley et al, Biol Psychiatry 2011; Hall et al Nat Neurosci 2006). Profs Jeremy Hall and Andrew McIntosh have also conducted (e.g. Selvaraj Bip Dis 2010;) and participated successfully in a number of international collaborative studies, resulting in internationally leading research, high impact publications (e.g. Stein et al 2012 Nat Gen; Ripke Nat Gen 2011) providing a pathway for future target identification and drug development.